TORONTO, April 8, 2014 – In a groundbreaking York University study, researchers have found that abnormal levels of lipid molecules in the brain can affect the interaction between two key neural pathways in early prenatal brain development, which can trigger autism. In addition, environmental causes such as exposure to chemicals in some cosmetics and common over-the-counter medication can affect the levels of these lipids.
“We have found that the abnormal level of a lipid molecule called Prostaglandin E2 in the brain can affect the function of Wnt proteins. It is important because this can change the course of early embryonic development,” explains Professor Dorota Crawford, Faculty of Health, who is a member of the York Autism Alliance Research Group.
This is the first time research shows evidence for cross-talk between PGE2 and Wnt signalling in neuronal stem cells, according to the peer reviewed study published in Cell Communication and Signaling.
Lead researcher and York U doctoral student Christine Wong adds, “Using real-time imaging microscopy, we determined that higher levels of PGE2 can change Wnt-dependent behaviour of neural stem cells by increasing cell migration or proliferation. As a result, this could affect how the brain is organized and wired. Moreover, we found that an elevated level of PGE2 can increase expression of Wnt-regulated genes – Ctnnb1, Ptgs2, Ccnd1, and Mmp9. Interestingly, all these genes have been previously implicated in various autism studies.”
Autism is considered to be the primary disorder of brain development, with symptoms ranging from mild to severe, including repetitive behaviour, deficits in social interaction, and impaired language. It is four times more prevalent in boys than in girls, and the incidence continues to rise. The US Center for Disease Control and Prevention (CDC) data from 2010 estimates that 1 in 68 children now have autism.
“The statistics are alarming," says Crawford. "It’s 30 per cent higher than the previous estimate of 1 in 88 children, up from only two years earlier. Perhaps we can no longer attribute this rise in autism incidence to better diagnostic tools or awareness of autism.
“It’s even more apparent from the recent literature that the environment might have a greater impact on vulnerable genes, particularly in pregnancy. Our study provides some molecular evidence that the environment likely disrupts certain events occurring in early brain development and contributes to autism.”
According to Crawford, genes don’t undergo significant changes in evolution, so even though genetic factors are the main cause of autism, environmental factors such as insufficient dietary supplementation of fatty acids, exposures to infections, and various chemicals or drugs may change gene expression and contribute to the disorder.
York University is helping to shape the global thinkers and thinking that will define tomorrow. York’s unwavering commitment to excellence reflects a rich diversity of perspectives and a strong sense of social responsibility that sets us apart. A York U degree empowers graduates to thrive in the world and achieve their life goals through a rigorous academic foundation balanced by real-world experiential education. As a globally recognized research centre, York is fully engaged in the critical discussions that lead to innovative solutions to the most pressing local and global social challenges. York’s 11 faculties and 27 research centres are thinking bigger, broader and more globally, partnering with 288 leading universities worldwide. York's community is strong − 55,000 students, 7,000 faculty and staff, and more than 250,000 alumni.
Media Contact:
Gloria Suhasini, York University Media Relations, 416 736 2100 ext. 22094, suhasini@yorku.ca
